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Image: Dr. Ravindra Kohle and Augusta OncoTarget; Copyright: Phil Jones / Augusta University

MCG lab designated to help with patient testing for NCI-MATCH trial

02/11/2018

The Georgia Esoteric and Molecular Laboratory at the Medical College of Georgia at Augusta University has been selected as a designated laboratory for the National Cancer Institute's Molecular Analysis for Therapy Choice, or MATCH trial, which is assessing the effectiveness of targeting cancer-causing gene changes rather than cancer type.
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Image: Brain; Copyright: panthermedia.net / Wavebreakmedia Itd.

Brain infection or cancer? A new rapid test could hold the answer

02/11/2018

When patients present with neurologic symptoms such as severe headaches or seizures, the symptoms could suggest anything from infection, cancer, or an autoimmune disease of the brain or spinal cord. The differences in diagnosis can mean having mere hours to act. Researchers at Jefferson have developed a test that could rapidly parse out infections of the brain from other diseases.
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Image: Raman microscopy to develop better cancer drugs; Copyright: panthermedia.net / Alex011973

Testing cells for cancer drug resistance

30/10/2018

Biophysicists at Ruhr-Universität Bochum (RUB) have demonstrated that Raman microscopy can be used to detect the resistance of tumour cells to cancer drugs. Unlike conventional approaches, this method does not require any antibodies or markers. It detects the response of cells to administered drugs and therefore could determine the effect of drugs in preclinical studies.
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Image: Antibody against tumor cells; Copyright: panthermedia.net / toeytoey

Novel method to block immunosuppression in cancer

29/10/2018

Belgian research groups from the UCLouvain and WELBIO, VIB and Ghent University, and the biotechnology company argenx elucidated the three-dimensional structure of an assembly of proteins that dampen immune responses. They also discovered how an antibody can block this assembly. Such an antibody could serve to stimulate immunity against tumor cells in cancer patients.
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Image: One of the largest trials to investigate a predictive blood test to guide cancer treatment; Copyright: panthermedia.net / londondeposit

Cancer blood test trialed to prevent unnecessary chemotherapy

19/10/2018

Cancer patients could be spared unnecessary chemotherapy - and its side effects - by a new blood test that is in clinical trials at more than 40 hospitals in Australia and New Zealand.
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Image: Woman in white coat looks at hologram with a heart; Copyright: panthermedia.net / Wavebreakmedia ltd

Computational model clarifies immune response during cardiac surgery

12/10/2018

A research team led by Peter Sloot, professor of Complex Adaptive Systems at the UvA, has managed to pinpoint the mechanisms behind the immune response triggered in patients undergoing open heart surgery.
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Image: A very promising vaccine for HER2-overexpressing cancers; Copyright: panthermedia.net / Esbenklinker

New cancer vaccine for patients with HER2-positive cancers

01/10/2018

Treatment with a HER2-targeted therapeutic cancer vaccine provided clinical benefit to several patients with metastatic HER2-positive cancers who had not previously been treated with a HER2-targeted therapeutic, according to data from a phase I clinical trial presented at the Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival.
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Image: The microscope image shows mitochondria, the cell's power plants; Copyright: AG Herrmann

Proteins surf to mitochondria – Novel transport pathway discovered

18/09/2018

Prof. Johannes Herrmann, a researcher at the Technische Universität Kaiserslautern, and his team discovered a novel mechanism by which newly synthesized proteins reach their respective target compartment in the cell. Proteins destined to mitochondria, are not directly transported to mitochondria but are directed to the surface of the endoplasmic reticulum.
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Image: Dr. Dao Nguyen looking at Pseudomonas aeruginosa; Copyright: McGill University Health Centre

New means to fight "un-killable" bacteria in healthcare settings

18/09/2018

Scientists at the Research Institute of the McGill University Health Centre (RI-MUHC) have identified new means of fighting drug-tolerant bacteria, a growing global threat as menacing as drug-resistant microbes. Little is known about the mechanisms leading to tolerance, a strategy that makes bacteria "indifferent" to antibiotics and almost "un-killable," which results in chronic infections.
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Image: Bacterial multiplication, which can lead to inflammations; Copyright: panthermedia.net / frenta

New nanoparticles wait to release drugs, target infection

17/09/2018

Current WSU research shows stimuli-responsive nanoparticles can specifically target infections to simultaneously prevent the spread of bacteria and reduce the inflammation it causes. These microscopic particles are loaded with antibiotic and anti-inflammatory agents which are released when the particles encounter infection in the body.
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Image: viral infectivity; Copyright: Lumacyte

New technology transforming vaccine development

13/09/2018

Could we finally have a faster, more objective analytical tool to rapidly measure viral infectivity for vaccine development and production? Scientists and bioengineers at Thermo Fisher Scientific and LumaCyte believe we do. This peer reviewed work is published in the prestigious journal, Vaccine, by Elsevier.
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Image: New tests for secondary heart attack risk; Copyright: Baker Heart and Diabetes Institute

New blood test to screen for secondary heart attack

07/09/2018

A blood test that quickly and easily detects whether a person is at risk of a secondary heart attack is being developed by scientists at the Baker Heart and Diabetes Institute.
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Image: A young man sitting at the curb with a laptop; Copyright: panthermedia.net/DragonImages

$8.8 million for Online HIV prevention program

03/09/2018

The National Institutes of Health (NIH) has awarded an $8.8 million grant to Keep It Up!, a novel online HIV prevention program that has been shown to reduce sexually transmitted infections in gay young men by 40 percent.
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Image: A single UVC light-diffusing optical fiber.; Copyright: David Welch, Ph.D., Columbia University Vagelos College of Physicians and Surgeons

'Safe' UV light may prevent infections

27/08/2018

Optical fibers that emit a type of UV light that's safe for skin--but deadly for drug-resistant bacteria--may be able to prevent infections around skin-penetrating medical devices
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Image: Three men in suits and a woman in a laboratory coat are standing in a laboratory; Copyright: Ministry of Economy of Mecklenburg-Hither Pomerania/Norbert Fellechner

On the trail of cancer: personalized cancer vaccine

01/03/2018

Conventional cancer treatment selection typically depends on the location of the tumor. However, this approach ignores the distinct gene mutations in the tumor of the individual patient. New cancer research approaches increasingly emphasize the concept of personalized therapy.
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Image: Collage of several MRI images of the heart, in which different locations are marked with red arrows; Copyright: University Hospital Münster/Ali Yilmaz

Myocarditis: more specific diagnosis thanks to molecular imaging

01/09/2017

There are many causes of myocarditis or inflammation of the heart muscle. Oftentimes, the culprits are viruses or bacteria and sometimes even an acute heart attack. Regardless of the cause, it creates a challenge for cardiologists: a diagnosis tends to be only nonspecific without a biopsy. A cardiac MRI and molecular imaging promise to provide assistance.
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Image: A petri dish with yellow bacterial cultures on a black ground; Copyright: panthermedia.net/kwanchaichaiudom

Laboratory medicine: confronting infections with speed and foresight

03/04/2017

The laboratory is one of the most important and pivotal bastions in patient care. In the laboratory, acute, chronic and genetic diseases are diagnosed, the progression of diseases such as diabetes is regularly checked or specialists look for biomarkers to adapt cancer therapies.
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Photo: Child gets pierced into the finger using a lancing device

Diabetes: comprehensive prevention, early "vaccination"?

08/04/2016

A diagnosis of diabetes often catches new patients off guard - for instance if they end up in the emergency room suffering from metabolic decompensation. Children are often affected by this. Their immune system destroys the insulin-producing cells in the pancreas early on in their lives, thus causing type 1 diabetes.
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Cancer Immunotherapy: Individual mutations as new target structures

01/06/2015

A tumor is as unique as the person who is affected by it. For a long time, it was assumed this would make treatment more difficult since cancer drugs are not able to be one hundred percent effective in targeting the affected cells. In this interview with MEDICA.de, Professor Ugur Sahin explains why it is precisely these individual mutations that make him hopeful for a new type of therapy.
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Multi-resistant bacteria want to conquer the world

01/08/2014

Bacteria lurk everywhere: on the skin, in the intestines and in every puddle. Most of them that are hanging out in the human body are good bacteria. But not all of them. Those pathogens that exhibit resistance and are thus very hard to combat are the most dangerous kind. Their spread threatens people all over the world.
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