Articles -- MEDICA - World Forum for Medicine

Image: Cells with Huntington's disease under the microscope; Copyright: Juan Sbodio

Signaling pathway involving the Golgi apparatus identified in cells with Huntington's disease


Working with cells grown in the lab, Johns Hopkins researchers have identified a biochemical pathway that allows a structure within cells, called the Golgi apparatus, to combat stress caused by free radicals and oxidants. The research team showed that this pathway can be activated by a drug called monensin, which is commonly used as an antibiotic in animal feed.
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Image: a man with two women in the laboratory; Copyright: RUB, Marquard

Bacteria produce more substances than hitherto assumed


The bacterium Streptomyces chartreusis is an antibiotic-producing bacterium that releases more metabolites into the surrounding medium than scientists assumed based on the analysis of the genome. Many of the substances are likely released to mediate interactions with its environment. They might also include molecules that are of interest as potential pharmaceutical agents.
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Image: man in a laboratory; Copyright: Helena Hiltunen

Bacteria-eaters to prevent food poisoning? Phages eliminate Yersinia from food


Bacteria-killing viruses could be employed not just in health care, but also in the food industry, a study conducted at the University of Helsinki indicates. The researchers have been investigating the possibility of utilising phages in eradicating foodborne pathogens and preventing food poisoning.
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Image: female apothecary stands in front of a large cupboard with medications; Copyright:

How old antibiotic compounds could become tomorrow's life-saving drugs


As the fight against drug-resistant infections continues, University of Leeds scientists are looking back at previously discarded chemical compounds, to see if any could be developed for new antibiotics.
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Image: digital screening mammography with fine calcifications (arrow) which resulted in the diagnosis of an aggressive preliminary stage of breast cancer; Copyright: UK Münster

Breast cancer discovered in its preliminary stages in mammography screening is usually aggressive


In the biennial mammography screening programme, the most frequent diagnosis of breast cancer in its preliminary stages is, biologically, the most aggressive form. High-grade ductal carcinoma in situ holds the greatest risk of developing into a so-called invasive carcinoma.
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Image: little girl at the doctor's, coughing and holding a hand in front of her mouth; Copyright:

For children with respiratory infections, antibiotics with narrower targets are better


CHOP researchers find outcomes are similar, but broader-spectrum antibiotics have higher risk of adverse effects.
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Image: smiling scientist - Dr. Mark Blaskovich; Copyright: University of Queensland

Supercharged antibiotics could turn tide against superbugs


An old drug supercharged by University of Queensland researchers has emerged as a new antibiotic that could destroy some of the world's most dangerous superbugs.
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Image: A petri dish with yellow bacterial cultures on a black ground; Copyright:

Laboratory medicine: confronting infections with speed and foresight


The laboratory is one of the most important and pivotal bastions in patient care. In the laboratory, acute, chronic and genetic diseases are diagnosed, the progression of diseases such as diabetes is regularly checked or specialists look for biomarkers to adapt cancer therapies.
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Image: Graphic representation of Europe with small figures depicting the population; Copyright: Segundo

Hospital-acquired infections: pathogens know no borders


Many aspects are uniformly regulated in Europe, however, hospital hygiene and MRSA prevention, for example, are not. The Netherlands plays a pioneering role in the fight against hospital-acquired infections. The country is an often-cited role model. But can other countries simply adopt the same system? And what makes it so different? MEDICA asked expert Prof. Alexander W. Friedrich.
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Photo: Large metal device with a pink glowing window in the fron

Plasmasterilization: active ingredient cocktail to fight bacteria


Until now, plasma, the fourth state of matter,was consideredfascinatingonly to astrophysicists and science fiction fans. But at this point, it also attracts the interest of medicine because plasma can have many uses in this field. In the future, plasma sterilization could become an important component of hospital hygiene-provided that the right device is being used.
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Photo: physicians at station

Gram-negative bacteria pose a major challenge for hospitals


Every day, people are admitted to the hospital, discharged or they visit patients. This large number of people increases the risk of bacteria transmission. Preventative measures such as short-sleeved uniforms and copper surfaces can help by improving hospital hygiene but they cannot replace the legal requirements for hygiene measures.
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Photo: Bacteria

Fecal microbiota transplantation: A stranger’s stool heals inflammatory bowel disease


It sounds strange: During fecal microbiota transplantation, the stool of a healthy donor is transferred into the intestines of a diseased patient to restore his or her damaged gut flora. This is an entirely normal process in the animal kingdom. Now the stool transplant has established itself as the standard for treating Clostridium difficile.
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