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Image: collagen from a healthy engineered lung tissue; Copyright: Ruogang Zhao

Lung-on-a-chip simulates pulmonary fibrosis

08/06/2018

Developing new medicines to treat pulmonary fibrosis, one of the most common and serious forms of lung disease, is not easy. One reason: it's difficult to mimic how the disease damages and scars lung tissue over time, often forcing scientists to employ a hodgepodge of time-consuming and costly techniques to assess the effectiveness of potential treatments.
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Image: 3D structure of the enzymatic active part of SdeA toxin; Copyright: Nature/Kalayil et al

Complementing conventional antibiotics

05/06/2018

Antimicrobial resistance is a major medical problem worldwide, impacting both human health and economic well-being. A new strategy for fighting bacteria has now been reported in the latest online issue of Nature by a research group headed by Prof. Dikic at the Goethe University Frankfurt. The scientists revealed the molecular action mechanism of a Legionella toxin and developed a first inhibitor.
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Image: Illustration of lung structure from CT scan data; Copyright: University of Southampton

How the power of mathematics can help assess lung function

21/05/2018

Researchers at the University of Southampton have developed a new computational way of analysing X-ray images of lungs, which could herald a breakthrough in the diagnosis and assessment of Chronic Obstructive Pulmonary Disease (COPD) and other lung diseases.
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Image: A simple protocol developed for insulin preparation; Copyright: Michio Iwaoka

High efficiency synthesis of insulin by self-assembly based organic chemistry

21/05/2018

Researchers at Tokai, Osaka, Tohoku and Fukuoka Universities report in the journal Communications Chemistry on the synthesis of insulin based on the self-assembly of polypeptide chains at about 40% efficiency.
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Image: two men in the laboratory next to the Organ Care System with a pig's lung inside; Copyright: Kaiser/MHH

Organ Care System: treatment under extreme conditions

08/05/2018

Multidrug-resistant organisms that are treated with a dosage that exceeds the regular dose a hundred times and at temperatures of over 40 degrees Celsius – the human organism is unable to handle it. Yet if the diseased organ is treated outside of the body, extreme conditions are an option. For the first time, physicians have succeeded in treating a severe case of pneumonia by using the OCS.
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Image: two men in the laboratory, one sitting at a microscope or similar, another standing behind him; Copyright: RUB, Kramer

Cancer drug observed at work

23/04/2018

Using a Raman microscope, researchers at Ruhr-Universität Bochum have studied at which targets the cancer drug Neratinib binds in cells and how its chemical structure changes. Compared with other techniques, this method offers a considerable advantage, as it is not necessary to apply a label to the drug that would indicate its distribution indirectly; rather, the drug itself can be monitored.
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Image: yellow tape measure with capsules in front of it; Copyright: panthermedia.net/Jiri Hera

Personalized cancer medicine: customized treatment

01/03/2018

Everyone is different. This statement also applies to our health. Cancer, in particular, can look and progress differently depending on the individual person. That’s why every patient ideally also needs a customized treatment that is tailored to their individual needs. But how feasible is this idea?
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Image: Young female student is sitting between shelves on the floor of a library and reads; Copyright: panthermedia.net/Brock Jones

Patient science: patients research cystic fibrosis

22/01/2018

Research does not always occur in laboratory settings. As part of citizen science, citizens collect data and make it available for research projects. Now, this approach is also adopted in medicine by way of patient science: in a new project, patients take part in cystic fibrosis research. The goal is to improve the lives of those who are affected by this chronic disease.
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Image: Man who is blowing into a smartphone adapter for breath tests; Copyright: THM/Gross/Sohrabi

AST@home: A rapid respiratory test for COPD using the smartphone

02/10/2017

Chronic obstructive pulmonary disease often requires a detailed documentation of the course. As part of the AST@home project, Professor Keywan Sohrabi and Professor Volker Groß at the THM developed an app that enables the monitoring of the course of COPD via smartphone and includes family members or nursing staff.
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Image: POCT-device and patient files; Copyright: panthermedia.net/gabriella

Point-of-care testing: helpful when things need to happen quickly?

01/08/2017

Advances in technology and analysis techniques, as well as the increasing miniaturization of laboratory equipment and processes, make it possible: patient-side laboratory testing, better known as point-of-care testing or POCT. There are many POCT projects and all of them promise a rapid diagnosis as well as economic advantages. But are these tests also suited for everyday medical testing?
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Image: woman holding a sketch of a human lung; Copyright: panthermedia.net/Monkeybusiness

Molecular Microsystems: Preventing Exacerbations of Asthma and COPD

01/08/2017

An increasing percentage of the world population suffers from chronic inflammatory disorders of the respiratory system. Acute attacks often lead to a worsening of the disease and considerably reduce the patient’s lung volume. Nine institutes of a research alliance under the Leibniz Institute umbrella are working on technologies designed to predict and thus prevent exacerbations.
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Image: Children playing outside, getting wet in the water; Copyright: panthermedia.net/Wavebreakmedia ltd

Pneumonia in Children: Ultrasound or X-Rays?

08/03/2017

Pneumonia is the most frequent respiratory disease in children and can even cause death. That is why it is extremely important to make an accurate diagnosis as quickly as possible. If this requires imaging tests, normally X-rays are taken. But there is an alternative: ultrasound.
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Lung cancer: A blood test evaluates the effectiveness of therapy

01/06/2015

Can liquid biopsies become the new trend in cancer diagnostics? The medical world has asked this question for quite some time. The first globally approved liquid biopsy-based test for lung cancer shows that this can work. Yet further findings and research are still required to establish this less invasive method in diagnostics.
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