22/03/2018Recent developments in neuroscience set high requirements for sophisticated data management, not least when implantable Brain Machine Interfaces are used to establish electronic communication between the brain's nerve cells and computers.
21/03/2018Scientists from the "Hopp Children's Cancer Center" at the NCT Heidelberg (KiTZ) and the Neuropathology Department at Heidelberg University Hospital have substantially enhanced the classification of tumors of the central nervous system (CNS).
16/03/2018Metabolic changes in cells can occur at the earliest stages of disease. In most cases, knowledge of those signals is limited, since we usually detect disease only after it has done significant damage.
16/03/2018The accumulation of mutations in the human genome is at the origin of cancers, as well as the development of resistance to treatments. The Cyclin E and Myc genes are active in the control of cell division. When they are mutated, for example in response to a carcinogen, these genes induce cells to start replicating their DNA prematurely during the cell cycle.
07/03/2018A research describes the anti-cancer effects of a natural alkaloid extracted from Daffodils. Led by Denis Lafontaine, affiliated with the Faculty of Sciences at the ULB, the researchers have discovered that this compound triggers the activation of an anti-tumoral surveillance pathway.
02/03/2018A bone marrow transplant is often the only therapy available to save leukaemia patients, but the risk of complications is high. In spite of devoting considerable time and effort to finding a suitable donor, nearly half of all patients experience an unwanted reaction of their immune system, which often attacks their skin and liver and in up to 50% of cases the intestines.
02/03/2018UZH researchers have discovered a previously unknown way in which proteins interact with one another and cells organize themselves. This new mechanism involves two fully unstructured proteins forming an ultra-high-affinity complex due to their opposite net charge. Proteins usually bind one another as a result of perfectly matching shapes in their three-dimensional structures.
01/03/2018Personalized medicine does not follow a "one-size-fits-all" treatment approach but emphasizes a "tailor-made" paradigm, meaning a treatment is customized to each individual person's case. For patients, this increases the chances of treatment success and means fewer side effects. While the approach originates in the field of oncology, it is now also increasingly applied to other disease patterns.
01/03/2018Academy Professor Riitta Lahesmaa’s research group from Turku Centre for Biotechnology of the University of Turku and Åbo Akademi University, Finland, has discovered a new regulator of the immune system, a key factor that controls development of regulatory T cells.
01/03/2018Conventional cancer treatment selection typically depends on the location of the tumor. However, this approach ignores the distinct gene mutations in the tumor of the individual patient. New cancer research approaches increasingly emphasize the concept of personalized therapy.
01/03/2018Everyone is different. This statement also applies to our health. Cancer, in particular, can look and progress differently depending on the individual person. That’s why every patient ideally also needs a customized treatment that is tailored to their individual needs. But how feasible is this idea?
22/02/2018Here on Earth, all experiments are bound by gravitation. Yet, freed from gravity's grip, tumor cells, for example, behave in an entirely different way. As part of the "Thyroid Cancer Cells in Space" project by the University of Magdeburg, smartphone-sized containers carrying poorly differentiated thyroid cancer cells are sent into space.
21/02/2018Research has identified gene variants that play a significant role in how women with ovarian cancer process chemotherapy.
15/02/2018Every kind of cancer can spread to the spine, yet two physician-scientists who treat these patients describe a paucity of guidance for effectively providing care and minimizing pain. To resolve the confusion and address the continually changing landscape of spine oncology, a recent Michigan Medicine-led publication details a guide to explain the management of spinal metastases.
14/02/2018Scientists at the University of Delaware and the University of Illinois at Chicago have found a new way to kill liver cancer cells and inhibit tumor growth. First, they silence a key cellular enzyme, and then they add a powerful drug. They describe their methods in a new paper published in Nature Communications.
09/02/2018Researchers at the Institute of Industrial Science (IIS), the University of Tokyo, CNRS and INSERM, report a new organ-on-a-chip technology for the study of blood vessel formation and drugs targeting this event.
07/02/2018Human papilloma virus (HPV), the culprit behind cervical cancer and some forms of head and neck cancer may hide in small pockets on the surface of tonsils in people not known to carry the virus.
07/02/2018Scientists from the University of Zurich have redesigned an adenovirus for use in cancer therapy. To achieve this they developed a new protein shield that hides the virus and protects it from being eliminated. Adapters on the surface of the virus enable the reconstructed virus to specifically infect tumor cells.
31/01/2018Screening a class of recently-developed drug compounds, so-called CDK inhibitors capable of blocking CDK7/12/13 proteins, against hundreds of different human cancer cell lines, researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center have found that CDK12 inhibitors pack a particularly lethal punch to Ewing sarcoma, a rare cancer typically affecting children and young adults.
30/01/2018Achievement in the field of cancer research: Biologists and chemists at the University of Konstanz decipher a molecular mechanism of the cell with relevance for the development of cancer and the fight against that disease. Particularly important is the interaction between the tumour-suppressor protein p53, known as the guardian of the genome, and the enzyme PARP-1, the caretaker of the genome.
29/01/2018Researchers at the Université libre de Bruxelles and University of Cambridge identified the role of key gene Mesp1 in the earliest step of cardiovascular lineage segregation. This discovery may help to better understand congenital heart defects.
24/01/2018Data collected during a long-term health study provides additional evidence for a link between increased risk of cancer in individuals with advanced gum disease.
18/01/2018An analysis of several hundred DIPG and related tumors, including Chad Carr's, finds an overlooked key factor in determining prognosis for the aggressive childhood brain cancer.
16/01/2018Researchers of the German Centre for Cardiovascular Research (DZHK) have discovered that patients with heart failure who have anorexia are also more affected in their physical functional capacity and have worse prognosis. Factors that encourage anorexia are the intake of diuretic medication, inflammation, and involuntary weight-loss.
15/01/2018A groundbreaking report, led by Professor Mark Lawler, Chair in Translational Cancer Genomics at Queen’s University Belfast highlights a plan to end bowel cancer, the second most common cause of cancer death in Europe.
04/01/2018Hokkaido University researchers have uncovered a cellular protein that stabilizes a tumor promoting signaling pathway, suggesting a new target to treat prostate cancer.
02/10/2017If you are interested in laboratory medicine and come to the MEDICA 2017, you will quickly notice that Exhibition Halls 1 and 2 were demolished. A new state-of-the art hall is meant to take their place. Until then, exhibitors from the field of laboratory medicine will be showcased at their temporary new location in the lightweight hall structures 3a and 18 on the fairgrounds.
01/09/2017Many people are affected by heart disease today because - among other reasons- our modern unhealthy lifestyle is taking a toll on our hearts. A reliable diagnosis and treatment are crucial for patients with heart disease since all other organs depend on the pumping of our vital organ. Modern imaging techniques are a key to understanding the heart.
22/08/2017Physics has always supported medical science, especially when it comes to practical implementation. Now physicists and health professionals join in collaborative research at an interdisciplinary Center in Erlangen and incorporate fundamental principles of theoretical physics in their studies of diseases.
10/07/2017Radiation therapies are an essential component of today’s oncology because they enable the treatment of localized tumors. Yet they have one major drawback: radiation damages not just tumor cells but also healthy tissue. One solution to solve this problem could be proton minibeam therapy, which uses finely focused beams.
03/07/2017Not all lasers are the same – especially in the surgical field, it all depends on what’s inside: the different operational wavelengths of laser light also affect human tissue in different ways. This is why a single laser for a variety of applications drastically simplifies the job of physicians.
03/07/2017The scalpel is considered the classic surgical instrument and as such, has remained unchanged for quite some time. However, today’s technology opens up a world of new possibilities for cutting tissue. Next to high-frequency electrosurgical scalpels that work with electric power, surgeons also use a variety of different lasers. They promise great usability and better treatment.
24/04/2017Liver cancer is the fifth most common malignant tumor in the world. The tumor can be removed through surgery or by utilizing thermal ablation techniques. If a treatment with conservative methods is no longer possible, there is an alternative: irreversible electroporation (IRE). The effectiveness of this method was now confirmed by a clinical study.
02/01/2017Our topic title "pediatric (children’s) oncology" evoked strong emotional reactions from several mothers and fathers of our staff. "This hits too close to home for me, I couldn’t write about it", or "How do people manage to deal with this?". And we are only on the sidelines; physicians, caregivers and nurses at the hospital, hospice or families at home are the ones that have the real tough job.
02/01/2017Treatments for children need to be different from treatment for adults – this also applies in oncology. Having said that, children do not just need new and different treatment concepts that still necessitate research. They also require the support from their families, who need to be nearby during treatment.
22/03/2016Medical apps like diabetes or high blood pressure diaries are becoming increasingly popular with smartphone users. There are many available choices out there but they are not always clear. Added to this is the question of how the data collected by the apps can be sensibly incorporated into treatment.
08/03/2016Pancreatic cancer is one of the deadliest forms of cancer because it is difficult to diagnose and only presents with symptoms in the later stages. In the future, a laboratory test developed at the Greifswald University Medicine could make an early detection of this type of cancer and consequently a faster and better treatment possible.
01/10/2015Semiconductor nanoparticles for biomedical applications have been researched for some time now. Not only are they millionths of a millimeter in size, they also offer great potential for cancer diagnostics and therapy, so-called theranostics. They enter cells, are activated by ultrasonic radiation and destroy the cells using the generated vibration.
01/10/2015It is a portmanteau, a mixture of two words. This way it saves us time and trouble while speaking because the human speech apparatus is lazy. And it describes a mixture of procedures: the combination of two procedures that would normally be separate in medicine. We are talking about theranostics.
01/10/2015A proper diagnosis is a part of great therapy. However, it can also be beneficial to be able to quickly respond to changes during a treatment. One example of this is the treatment of uterine myomas. Female patients at the University Hospital Bonn are treated using so-called high-intensity focused ultrasound, HIFU in short. Prof. Holger Strunk explains this procedure.
03/08/2015Endoradiotherapy can be very unpleasant for cancer patients, since it does not only harm tumor cells, but also healthy ones. Sometimes, patients even need to stop therapy because of the side effects. Physicians and researchers are thus continuously searching for ways to transport radiopharmaceuticals directly and exclusively to their target.
01/06/2015Can liquid biopsies become the new trend in cancer diagnostics? The medical world has asked this question for quite some time. The first globally approved liquid biopsy-based test for lung cancer shows that this can work. Yet further findings and research are still required to establish this less invasive method in diagnostics.
01/06/2015A tumor is as unique as the person who is affected by it. For a long time, it was assumed this would make treatment more difficult since cancer drugs are not able to be one hundred percent effective in targeting the affected cells. In this interview with MEDICA.de, Professor Ugur Sahin explains why it is precisely these individual mutations that make him hopeful for a new type of therapy.
01/06/2015When cancer is diagnosed, the terms tumor markers or biomarkers keep popping up. They describe characteristics that are not found in healthy persons. The classic tumor markers can be easily detected in blood samples or other body fluids. Other analysis methods require more effort. Yet they all share one thing in common: biomarkers indicate a potential tumor.
04/05/2015Whether it is a mammogram, colonoscopy or a skin cancer screening – after a certain age, we are subject to various early cancer detection screenings. Yet many of us don’t know that these screening tests are also associated with risks. This is something what Dr. Sylvia Sänger from the University Medical Center Hamburg-Eppendorf discovered in a study.
04/05/2015Since the end of April 2015, the long-awaited evaluation report on the skin cancer screening programs offered by German health insurance providers is now finally available. We spoke with Dr. Ralph von Kiedrowski, Board Member of the German Dermatologist Association (German: Berufsverband Deutscher Dermatologen) on what the screening can accomplish and his take on the G-BA report.
04/05/2015There are many decisions to be made in an adult life; among them are cancer prevention screenings. They are voluntary and many people deliberate whether they should go or not and if they would actually want to know the results. Science, politics and health care professionals also ponder with each new preventive service whether it is beneficial and who should end up paying for it.
02/02/2015Only projects with a solid foundation are successful in the long run. This is also true for science. Biobanks are the most important component of this foundation when it comes to fundamental biomedical research: Only high quality tissue samples that are stored there make conclusive research possible - for example in search of the causes of tumorigenesis.
03/11/2014As an imaging procedure, magnetic resonance tomography has become essential in clinical practice, since it can easily make organs and tissue visible. However, until now abnormal cancer cells or small centers of inflammation remained almost invisible. Now cell biologists from Berlin, Germany, have succeeded in fixing this problem with xenon magnetic resonance imaging.
03/02/2014Differentiating tumor tissue from healthy tissue isn’t always easy for surgeons. Scattered cancer cells and early cancer are often hard to detect with the naked eye. A special camera now makes even the tiniest remainder of a tumor visible during surgery.
03/02/2014Shortening a time-consuming procedure from four hours to five minutes and automate it at the same time sounds like a dream come true for employees in all fields and industry sectors. This dream could soon become a reality for radiologists. Software could take away the tedious processing of CT images, which is required before cancer radiation therapy.
03/02/2014Radiologists usually do their work after oncologists when it comes to cancer treatment. Yet modern radiology also provides treatments at this point. MEDICA.de spoke with Professor Stefan Schönberg, Director of the Institute of Clinical Radiology and Nuclear Medicine at the University Medical Center Mannheim, Germany, about the use of a new computer tomograph and its benefits for patients.
05/01/2014Eventually, all adults need to see a physician for colon cancer prevention. While the exam goes by quickly thanks to sedation, it sometimes leads to a follow-up procedure if a growth in the colon could not be removed with the endoscope and requires open surgery.