When major arteries are affected by atherosclerosis, fatty deposits, or plaques, accumulate on the inner lining of the vessel walls. Progression of the disease over time leads to narrowing, restricting blood flow or becoming completely blocked. Until recently, scientists believed that this narrowing, called stenosis, was responsible for most heart attacks or strokes.
But new studies have identified the composition of complicated plaques as being a major cause of vascular events and deaths. These plaques are characterised by surface ulcerations, blood clots and bleeding into the vessel wall. "There's been a major sea change in our research," said Alan R. Moody of the University of Toronto. "We now know that the composition of carotid artery plaque is likely to be more predictive of future stroke events than the amount of stenosis in the vessel."
The results of the new study suggest the 3-D MRI technique may prove to be a useful screening tool for patients at high risk for stroke. In the study, researchers performed 3-D MRI on the carotid arteries of eleven patients, age 69 to 81. Complicated plaques were then surgically removed from the patients' diseased arteries and analysed under a microscope.
The research team found strong agreement between the lesions identified by MRI as complicated plaques and the microscopic analysis of the tissue samples. "With high spatial resolution 3-D MRI, we are able to noninvasively analyse the tissue within the artery wall and identify small bleeds within rupture-prone plaques that may put patients at risk for future stroke," Moody said.
According to Moody, 3-D MRI is a tool that is ideally suited to screen high-risk patients for complicated carotid plaques and to monitor the effects of interventions designed to slow the progress of the atherosclerotic disease. The technique is easy to perform and interpret and takes only a few minutes when added to an MR angiography study, he said.
MEDICA.de; Source: Radiological Society of North America