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Improved Method of Electrical Stimulation Could Help Treat
FES was developed to help return lost function to patients with upper and lower extremity injuries and spinal cord injuries, among other applications. However, the devices, which work by stimulating neuronal activity in nerve-damaged patients, have a potential shortcoming in that the electrical currents needed for the treatment to work can also send errant signals to surrounding nerves, resulting in painful side effects.
"This new device works by manipulating the concentration of charged ions surrounding the nerve," explains Doctor Samuel J. Lin, a surgeon in BIDMC's Divisions of Plastic Surgery and Otolaryngology. "This could potentially mean reduced risk to surrounding nerves because less electrical current is required to stimulate the affected nerve." The researchers additionally discovered that they could use the device to block signals in nearby nerve fibres, which could help prevent unwanted muscle contractions.
The research team determined that by altering calcium ion concentrations in the fluid surrounding the nerves they could adjust the electrical impulses.
"Nerve fibres fire their signals based on the message they receive from the interaction of ions, or charged particles," explains Doctor Ahmed M.S. Ibrahim. "We wanted to achieve the lowest current possible that would still result in positive results." After testing the manipulation of sodium and potassium ions, the researchers determined that consistent results could be achieved by removing positively charged calcium ions from the fluid surrounding the nerves.
The newly designed method not only prevents electrical impulses from travelling along a nerve but also uses significantly less current required by existing FES therapy. "This could be of particular benefit for the treatment of patients with various forms of paralysis," explains Lin. "The nerves that control movements and the sensory nerves that carry pain signals are extremely close together, so existing FES therapy has had limitations."
The researchers conducted their study of this new electrochemical-stimulation method in the nerves of frogs and plan to later test it in mammalian nerves.
MEDICA.de; Source: Beth Israel Deaconess Medical Centre (BIDMC)