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Probiotic Protects Intestine from Radiation Injury
Radiation therapy often is used to treat prostate, cervical, bladder, endometrial and other abdominal cancers. But the therapy can kill both cancer cells and healthy ones, leading to severe bouts of diarrhoea if the lining of the intestine gets damaged.
"For many patients, this means radiation therapy must be discontinued, or the radiation dose reduced, while the intestine heals," says Doctor William F. Stenson. "Probiotics may provide a way to protect the lining of the small intestine from some of that damage."
Stenson has been searching for ways to repair and protect healthy tissue from radiation. This study showed that the probiotic bacteria Lactobacillus rhamnosus GG (LGG), among other Lactobacillus probiotic strains, protected the lining of the small intestine in mice receiving radiation.
The researchers found that the probiotic was effective only if given to mice before radiation exposure. If the mice received the probiotic after damage to the intestinal lining had occurred, the LGG treatment could not repair it in this model.Because the probiotic protected intestinal cells in mice exposed, the investigators believe it may be time to study probiotic use in patients receiving radiation therapy for abdominal cancers.
Previously, Stenson and his colleagues demonstrated that a molecular pathway involving prostaglandins and cyclooxygenase-2 (COX-2), key components in inflammation, could protect cells in the small intestine by preventing the programmed cell death, or apoptosis, that occurs in response to radiation.
They gave measured doses of LGG to mice, directly delivering the live bacteria to the stomach. They found it protected only mice that could make COX-2. In mutant mice unable to manufacture COX-2, the radiation destroyed epithelial cells in the intestine, just as it did in mice that didn't receive the probiotic.
"In the large intestine, or colon, cells that make COX-2 migrate to sites of injury and assist in repair," Ciorba says. "In this study, we evaluated that response in the small intestine, and we found that COX-2-expressing cells could migrate from the lining to the area of the intestine, called the crypt, where new epithelial cells are made, and we believe this mechanism is key to the protective effect we observed."
MEDICA.de; Source: Washington University School of Medicine in St. Louis