Fluorescent-tagged Chloroquine Enable Easy and Direct Visualization of Drug action and localization

The fluorescent-tagged chloroquine has been validated pharmacologically similar (i.e. uptake and localization) to chloroquine, and selectively accumulates within the digestive vacuole (DV) of chloroquine-sensitive Plasmodium falciparum parasites, as well as within the lysosomes of mammalian cells. Henceforth, LynxTag-CQ™BLUE and LynxTag-CQ™GREEN demonstrate multipul potentials in the domains of drug resistance screening and bioimaging applications.

LynxTag-CQ ™BLUE and LynxTag-CQ™GREEN are anticipated to be significant in the elucidation of drug-resistance and growth-related pathways, as well as to advance the current knowledge base and understanding for differing plasmodium species and related parasitic diseases.

Key Advantages
1. Easy to use. Live cell visualization using Fluorescent-Tagged Drugs (FTDs) requires neither specialized nor complex equipment, or reagents other than flow cytometry or fluorescence microscopy setups, which would allow even small-scale laboratories to utilize this technology
2. Enables in vitro visualization of drug localization in live cells. For drug resistance mechanism studies, it is important to be able to track and record the movement of drugs within live cells.
3. Does not alter the effectiveness of the drug. These FTDs have been shown not to interfere with cellular pathways in the host cell, which results in more precise and useful information pertaining to drug-cell interactions.

Visit us at http://www.biolynxtech.com for more information.