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Hormonal Role in Glucose and Fat Metabolism
They now believe that this oestrogen hormone is a prominent regulator of several body functions in both females and males. While estradiol is more commonly associated with processes and diseases specific to women, the team determined that the hormone actually functions as a unisex hormone with multiple actions. Research has indicated that when there is an excessive or insufficient amount of estradiol present, the metabolic network becomes imbalanced, which can result in metabolic diseases.
"Female hormones have always been associated with the menstrual cycle, pregnancy, breast-feeding and some diseases, such as osteoporosis and breast cancer, typically associated with women," said Doctor Rodrigo Barros of the UH Centre for Nuclear Receptors and Cell Signalling (CNRCS). "Our group, however, has discovered that one of these hormones, estradiol, has much wider actions than previously thought. It is no longer considered exclusively a 'female sex hormone,' but a 'unisex hormone' with multiple actions across several organ systems."
Working with CNRCS director and Professor Jan-Åke Gustafsson, Barros says that part of their research is dedicated to understanding how estradiol regulates feeding and food metabolism, explaining that this hormone is involved with several metabolic diseases, including eating disorders, obesity and diabetes.
"We believe that all the systems in the body involved with food consumption and metabolism, which include the brain, liver, pancreas, heart, muscles and fat, are connected by estradiol, resulting in a 'metabolic network' regulated by the hormone," Barros said. "Our evidence shows that when too much or too little estradiol is available, this delicate network loses its balance and metabolic diseases set in."
This research has important implications for the average consumer, as well as for physicians. While hormones like estradiol are important for the adequate maintenance of body functioning, they may pose serious risks to a person's health if misused as supplements. This comes into play when people use alternative forms of hormones, such as natural plant derivatives, that may be harmful if used inappropriately.
MEDICA.de; Source: University of Houston