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DNA Regions Influencing Prostate Cancer Risk
Men with relatives who have been
diagnosed with prostate cancer have
an elevated risk of also developing
this type of cancer; © pantherme-
dia.net / Monkeybusiness Images
Doctors have known for a long time that prostate cancer “runs in the family”. Men with relatives who have been diagnosed with prostate cancer have an elevated risk of also developing this type of cancer.
The exact DNA variants that contribute to prostate cancer risk have now been published by an international research consortium, a collaboration of 48 institutes worldwide, with participation of scientists from the German Cancer Research Center.
Such DNA variants are scientifically called single nucleotide polymorphisms (SNPs). They are defined as a single variation of a nucleotide which occurs with varying frequency in the whole population. If a relationship in numbers is found between a particular SNP and cancer incidence, researchers conclude that a gene within the affected DNA region plays a role in cancer.
The first two study stages conducted by the consortium had already identified 16 SNPs in 16 different DNA regions to be associated with an elevated prostate cancer risk. Together with the results of prior association studies, about 30 risk genes for prostate cancer were known then. In the third and last round the research consortium searched in 4.574 cancer patients and 4.164 controls for another 1.536 SNPs. The emerging associations with cancer risk were then verified once more using 51.311 DNA samples of cancer patients and healthy men.
Alongside a number of already identified variants, the investigators found seven SNPs that emerged for the first time in association with an elevation in prostate cancer risk. The variants are all located in DNA regions that also contain genes for which the scientists consider it plausible that they play a role in carcinogenesis. However, an association with the malignancy of cancer could not be established for any of these variants. With the seven newly discovered DNA regions, scientists are now able to explain about 25 percent of familial cancer risk.
MEDICA.de; Source: German Cancer Research Center