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Integrated Optical Trap Holds Particles
With the help of the new particle
trap viruses can be rapidly detected;
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"Ultimately, it could have applications for rapid detection of bacteria and viruses in hospitals, for cell sorting in research labs, and for process monitoring in chemical engineering," said Holger Schmidt, professor of electrical engineering and director of the W. M. Keck Center for Nanoscale Optofluidics at University of California, Santa Cruz.
The new technique offers the potential to create a smaller, cheaper version of the sophisticated equipment used to perform fluorescence-activated cell sorting (FACS), Schmidt explained.
"The capabilities of our optofluidic platform are continuing to grow. We have gone from the detection of single molecules and single viruses to now being able to control the movement of particles," he said.
Optical traps and "optical tweezers" use the momentum carried by the photons in a beam of light to exert forces on microscopic objects, enabling researchers to manipulate objects ranging from biological molecules to living cells. Schmidt's group developed a new way to perform optical trapping on a chip-based platform.
The technique relies on an earlier innovation from Schmidt's lab: a hollow-core optical waveguide that can direct a beam of light through a liquid-filled channel on a chip. To trap particles, the researchers used two laser beams at opposite ends of a channel. A particle gets trapped at the point where the forces exerted by the two beams are equal, and the particle can be moved by changing the relative power of the two laser beams.
"We can also use this like an optical leaf blower to push all the particles in a sample to the same spot and increase the concentration," Schmidt said. "The goal is to control the position and movement of particles through channels on a chip so they can be studied using fluorescence analysis and other optical methods."
MEDICA.de; Source: University of California, Santa Cruz