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Study shows functional effects of human stem cell delivery to heart muscle after heart attack


Researchers delivered human stem cells seeded in biological sutures to the damaged heart muscles of rats following induced acute myocardial infarction and assessed the effects on cardiac function one week later.
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Image: A protected, inactive form of the peptide on the left, and a free, active form of the peptide on the right side; Copyright: Empa

Peptides vs. superbugs


Several peptides have an antibacterial effect - but they are broken down in the human body too quickly to exert this effect. Empa researchers have now succeeded in encasing peptides in a protective coat, which could prolong their life in the human body. This is an important breakthrough because peptides are considered to be a possible solution in the fight against antibiotic-resistant bacteria.
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New library of human stem cells with the Brazilian genetic admixture


New human pluripotent stem cells lines are derived from individuals of the Brazilian population - with European, African and Native American genomic ancestry; they can be used for testing drug toxicity and for studying differential drug response
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Alzheimer's disease could be treated with gene therapy, suggests animal study


Researchers have prevented the development of Alzheimer's disease in mice by using a virus to deliver a specific gene into the brain.
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Causative gene for sensorineural hearing loss identified


A causative gene for a highly common type of hearing loss (sensorineural hearing loss, or SNHL) has been identified by a group of Japanese researchers, who successfully replicated the condition using a transgenic mouse. This discovery could potentially be used to develop new treatments for hearing loss. The findings were published in the online version of EMBO Molecular Medicine.
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Study reveals a biological link between stress and obesity


For the first time - researchers revealed a connection between anxiety and metabolic disorders at the molecular level; the discovery opens new possibilities for detecting and treating both symptoms.
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New strategy identified for treating acute myeloid leukemia


A multi-institutional academic and industry research team led by investigators from Massachusetts General Hospital (MGH) and the Harvard Stem Cell Institute has identified a promising new approach to the treatment of acute myeloid leukemia (AML).
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Multifaceted genetic impact of training


Endurance training changes the activity of thousands of genes and give rise to a multitude of altered DNA-copies, RNA, researchers from Karolinska Institutet report. The study, which also nuances the concept of muscle memory, is published in the journal PLOS Genetics.
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Unique molecular atlas of pancreas produced


Researchers at Karolinska Institutet have managed to produce the first molecular map of the genes that are active in the various cells of the human pancreas. They have also revealed differences in genetic activity between people with type 2 diabetes and healthy controls.
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Precision medicine trial shows benefit to patients


A clinical trial for types of advanced cancer is the first of its kind to show that precision medicine - or tailoring treatment for individual people - can slow down the time it takes for a tumor to grow back, according to research presented at the Molecular Analysis for Personalized Therapy (MAP) conference.
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Image: Graphic showing a model of the human heart and ECG curves; Copyright: Tobias Brügmann (University Bonn)/Patrick M. Boyle (John Hopkins University)

Termination of lethal arrhythmia with light


A research team from the University of Bonn has succeeded for the first time in using light stimuli to stop life-threatening cardiac arrhythmia in mouse hearts. Furthermore, as shown in computer simulations at Johns Hopkins University, this technique could also be used successfully for human hearts.
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Software helps to find out why "jumping genes" are activated


Jumping genes, so-called transposons, reproduce as parasites in the genome. This selfish behavior can be an evolutionary advantage for the organism or harm it. There is still a debate about the factors controlling the activity of transposons.
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Scientists develop DNA-altering technology to tackle diseases


Researchers in Singapore have developed a new protein that can alter DNA in living cells with much higher precision than current methods.
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Study shows how Chinese medicine kills cancer cells


Researchers at the University of Adelaide have shown how a complex mix of plant compounds derived from ancient clinical practice in China – a Traditional Chinese Medicine – works to kill cancer cells.
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Study opens door to targeted treatments for esophageal cancer


Potential outbreaks of diseases such as Ebola and Lassa fever may be more accurately predicted thanks to a new mathematical model developed by researchers at the University of Cambridge. This could in turn help inform public health messages to prevent outbreaks spreading more widely.
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First project on Charcot-Marie-Tooth Disease


BioPontis Alliance for Rare Diseases, a unique international nonprofit organization, and VIB, an excellence-based Life Science Research Institute in Belgium, announced a strategic partnership in rare diseases. The first program is aimed at developing a treatment for one type of Charcot Marie Tooth disease (CMT), a rare, progressive and invalidating neuropathy.
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A new path for killing pathogenic bacteria


Bacteria that cause tuberculosis, leprosy and other diseases, survive by switching between two different types of metabolism. EPFL scientists have now discovered that this switch is controlled by a mechanism that constantly adapts to meet the bacterium's survival needs, like a home's thermostat reacting to changes in temperature.
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A molecular alarm clock awakens resting ovules


Researchers discovered in the fruit fly a molecular "alarm clock" that tells resting ovules when is the right time to wake up. Defects in this alarm clock result in female fertility problems.
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New maths to predict dangerous hospital epidemics


Mathematicians are now developing completely new statistical calculations on the world’s fastest computers in order to be able to predict how epidemics of dangerous hospital bacteria spread. Studying the entire genomes of bacteria has now thrown open entirely new possibilities for revealing their secrets. It is this genetic knowledge that scientists use to understand bacterial epidemics.
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Brain study confirms gene mutation link to psychiatric disorders


Brain scans have revealed how a genetic mutation linked to major psychiatric disorders affects the structure, function and chemistry of the brain.
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Fidgeting helps prevent arterial dysfunction from sitting


Previous research has shown that sitting for an extended period of time at a computer or during a long airline flight reduces blood flow to the legs, which may contribute to the development of cardiovascular disease. Now, researchers from the University of Missouri have found that fidgeting while sitting can protect the arteries in legs and potentially help prevent arterial disease.
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Study finds hundreds of genes and genetic codes that regulate genes tied to alcoholism


Using rats carefully bred to either drink large amounts of alcohol or to spurn it, researchers at Indiana and Purdue universities have identified hundreds of genes that appear to play a role in increasing the desire to drink alcohol.
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Leaky calcium triggers brainstem blackout that results in sudden cardiac death


Epilepsy is an extremely common disorder affecting people of all ages, from infants through teenagers to older adults. One of the most mysterious things about this disorder is that about 6 percent of the people with epilepsy have an unusually high incidence of sudden unexpected death.
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Diabetes: comprehensive prevention, early "vaccination"?


A diagnosis of diabetes often catches new patients off guard - for instance if they end up in the emergency room suffering from metabolic decompensation. Children are often affected by this. Their immune system destroys the insulin-producing cells in the pancreas early on in their lives, thus causing type 1 diabetes.
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Human Genetics: "Physicians should be able to counsel patients on the process"


Human genetics is the study of the genetic makeup of human beings. DNA, chromosomes, and genes are extensively analyzed by medical specialists. Physicians of Germany need to have a qualification in genetic counseling to successfully advise patients.
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Point-of-care-testing: from disc to diagnosis


Easy solutions that deliver results quickly are a great asset in medicine: patients receive their diagnosis faster and physicians have more time to treat them. Such tools also work without sophisticated resources and trained personal. A device currently developed in a project funded by the European Commission could bring all of this to point-of-care-testing for infectious diseases.
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Multiple Sclerosis: does the colon affect the immune system?


Multiple sclerosis apparently can strike anyone - regardless of age, family history, lifestyle or gender. Yet why then does it not strike everyone? Genetic and environmental factors appear not to be the only reason whether it develops or not. The countless microorganisms that colonize our intestinal tract could also be involved in this.
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Direct-To-Consumer Testing: the business with lifestyle tests


The many possibilities the Internet offers also don’t shy away from laboratory medicine. The demand for biochemical or genetic tests continues to rise. Next to standard laboratory tests, a market developed in which the patient is the immediate recipient of clinical results. New distribution channels eliminate the physician as the responsible party.
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Cancer Immunotherapy: Individual mutations as new target structures


A tumor is as unique as the person who is affected by it. For a long time, it was assumed this would make treatment more difficult since cancer drugs are not able to be one hundred percent effective in targeting the affected cells. In this interview with, Professor Ugur Sahin explains why it is precisely these individual mutations that make him hopeful for a new type of therapy.
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Cancer prevention: Beneficial and ultimately personal


There are many decisions to be made in an adult life; among them are cancer prevention screenings. They are voluntary and many people deliberate whether they should go or not and if they would actually want to know the results. Science, politics and health care professionals also ponder with each new preventive service whether it is beneficial and who should end up paying for it.
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IBD: When genetics and environment interact


T-cells are the guardians of our immune system. When they show changes, it can lead to severe inflammatory responses in the body. It is believed that the T-cells in persons who are affected by inflammatory bowel disease don’t work properly. Two proteins that can be found on activated T-cells and that interact with each other are now being analyzed.
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Genetics: “We try to simplify diagnosis for rare diseases“


Sometimes your TV is actually right and diagnosing an illness is really a puzzle. This is the case with rare diseases for example, which only affect a small portion of the population. Physicians are then confronted with the problem of not having enough experience with a specific illness and its symptoms to be able to make a diagnosis.
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Vascular health in athletes


"Sports are good for your health", as the saying goes. Regular exercise promotes the health of our blood vessels and prevents vascular diseases. However, many years of competitive sports can also have negative effects on vascular health and increase the risk of myocardial infarction. Prof. Martin Halle of the Technical University Munich explains at what athletes need to pay attention to.
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