Worse Prognosis for Younger Patients

Photo: Colon cancer

Patients under age 50 with colo-
rectal cancer had more poorly
differentiated tumours than older
patients; © panthermedia.net/
Sasa Ilic

"We are seeing more advanced tumours in this population because the cases aren't being caught early enough," said Mitchell. "Screening is not recommended until age 50, and the younger a patient is, the more likely they are to ignore symptoms of more advanced stages of the disease."

The objective of this study was to assess pathological features and outcomes of colorectal cancer in patients less than age 50 using an institutional sample and comparing to the Surveillance, Epidemiology and End Results (SEER) database.

Mitchell and colleagues obtained data from the tumour registry of Thomas Jefferson University Hospital (TJUH) on 4,595 patients treated for colorectal cancer from 1988 to 2007. They compared those data with data obtained from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) database on 290,338 patients with colorectal cancer treated from 1988 to 2004. The researchers collected data on location, stage and histologic grade of the cancer.

Patients under age 50 with colorectal cancer presented with more advanced stage tumours in both data sets (SEER and TJUH), and had more poorly differentiated tumours than older patients, the researchers found. Patients under 50 also had more mucinous/signet ring cell tumours with 12 per cent to 8.1 per cent in the TJUH data and 13.2 per cent to 10.3 per cent in the SEER data, with younger males having the highest prevalence in both data sets.

Younger patients had fewer right-side tumours than patients 50 and over, and a higher proportion of rectal tumours. Patients under age 50 were also more likely to have positive nodes at all stages relative to 50 and over, as well as more likely to develop peritoneal metastases, but less likely to have lung metastases than older patients.

"Ongoing studies will help clarify the survival disparity and assess differences in treatment and molecular features between younger and older colorectal cancer patients," Mitchell said.

MEDICA.de; Source: Thomas Jefferson University