Worms May Be Useful to Fight Bowel Disease

A whipworm egg - the human
immune system may profit from
exposure to it; © PHIL

Researcher Linda Mansfield at Michigan State University is part of a national team of scientists investigating the role that parasites can play in treating inflammatory bowel disease, or IBD, in humans. Some researchers argue that improved hygiene throughout the developed world may be responsible for inflammatory bowel disease, as well as a whole range of autoimmune disorders. According to this "hygiene hypothesis," immune systems require exposure to infections of all sorts early in life in order to develop sufficiently.

Intriguingly, inflammatory bowel disease, which has two forms – Crohn’s disease and ulcerative colitis – is virtually unknown in the developing world, while it is increasing dramatically in developed societies. When people from developing countries move to developed ones, their incidence of the disease tends to increase.

"We know from veterinary medicine that many bacterial and protozoan pathogens, especially those that multiply inside of cells, elicit an immune response in the host that would normally cause inflammation, but that worm parasites mount an anti-inflammatory defense that modulates it," said Mansfield, a professor of large animal clinical sciences. "The greater the immune response, the greater the anti-inflammatory effect. It is possible that the human immune system developed in a way that is dependent on parasitic worms to regulate immune responses."

The particular worm that Mansfield and colleagues are studying as a potential treatment is known as the whipworm, or Trichuris suis, which is a parasite that afflicts pigs. Early studies have shown that giving humans a concoction of whipworm eggs and Gatorade is very effective in treating inflammatory bowel disease.

MEDICA.de; Source: Michigan State University