Mark Pereira, senior author on the study, said people who consume soft drinks on a regular basis, defined as primarily carbonated sugar-sweetened beverages, tend to have a poor behavioural profile overall. However, the effect of these drinks on pancreatic cancer may be unique. "The high levels of sugar in soft drinks may be increasing the level of insulin in the body, which we think contributes to pancreatic cancer cell growth," said Pereira.
For the current study, Pereira and colleagues followed 60,524 men and women in the Singapore Chinese Health Study for 14 years. During that time, there were 140 pancreatic cancer cases. Those who consumed two or more soft drinks per week (averaging five per week) had an 87 percent increased risk compared with individuals who did not. No association was seen between fruit juice consumption and pancreatic cancer.
Pereira said that these results from Singapore are likely applicable to the United States. "Singapore is a wealthy country with excellent health care. Favourite pastimes are eating and shopping, so the findings should apply to other western countries," said Pereira.
Susan Mayne, associate director of the Yale Cancer Center, said these study results are intriguing but have some key limitations that should be considered in any interpretation. "Although this study found a risk, the finding was based on a relatively small number of cases and it remains unclear whether it is a causal association or not. Soft drink consumption in Singapore was associated with several other adverse health behaviours such as smoking and red meat intake, which we can't accurately control for," said Mayne.
Pereira points out that the findings are biologically plausible, held up in non-smokers, remained similar after taking other dietary habits into account and are consistent with findings in Caucasian populations.
MEDICA.de; Source: American Association for Cancer Research