"Keeping glucose levels from jumping too high or dipping too low may help to reduce the risk of cardiovascular disease, which has been connected to erratic glucose levels in those with diabetes," said Robert Gabbay, M.D., Ph.D., associate professor of medicine at Penn State College of Medicine.
"Our study shows that after a high carbohydrate, high fat meal like pizza used in this study, spacing out insulin given by an insulin pump in two doses, one of which is over an eight-hour period, may keep glucose levels in a more favourable range than a single dose of insulin or a double dose taken over a shorter period," Gabbay adds.
Twenty-six volunteers with type 1 diabetes were selected from the patient population at Penn State Hershey Medical Center and were outfitted with a new glucose monitoring system that averages blood glucose levels every five minutes. For three days, volunteers ate an evening meal of plain cheese pizza with water.
Mean glucose levels after eating the pizza were 133 mg/dl for the day one single dose of insulin, 145 mg/dl for the two-stage, four-hour administration of insulin, and 104 mg/dl for the two-stage, eight-hour administration of insulin. The suggested target glucose range is typically between 80 mg/dl and 124 mg/dl.
"We showed that the eight-hour extended dose of insulin better controlled post-meal glucose levels and did not decrease glucose levels enough to cause any hypoglycemic events, which is unusual. Blood glucose control after a pizza meal was improved by extending the time of delivery of insulin to eight hours without varying the total amount of insulin administered," Gabbay said
"For now, generalisation to food types other than pizza may best be based on foods that are known to cause the same type of prolonged hyperglycemia and not necessarily those that have only the same composition," he said.
MEDICA.de; Source: Penn State University