25/08/2016Bacteria that cause tuberculosis, leprosy and other diseases, survive by switching between two different types of metabolism. EPFL scientists have now discovered that this switch is controlled by a mechanism that constantly adapts to meet the bacterium's survival needs, like a home's thermostat reacting to changes in temperature.
24/08/2016A discovery in the field of biomaterials may open new frontiers in stem and cancer cell manipulation and associated advanced therapy development. Novel scaffolds are shown enabling cells to behave in a different but controlled way in vitro due to the presence of aligned, self-assembled ceramic nanofibers of an ultra-high anisotropy ratio augmented into graphene shells.
23/08/2016An estimated 23,000 people in the U.S. die each year of antibiotic resistant bacterial infections, according to the Centers for Disease Control and Prevention (CDC). A UK government-commissioned review reports that such infections take 700,000 lives per year globally.
20/07/2016Each year, about 170,000 people die of complications of hepatic cirrhosis in Europe. Frequent causes of the widespread disease include alcohol abuse, fatty liver hepatitis, and chronic viral hepatitis. Liver cirrhosis develops gradually over a period of years and decades.
04/07/2016A receptor, first known for its role in mediating the harmful effects of the environmental pollutant dioxin in our body, is now understood to play other important roles in modulating the innate immune response.
21/06/2016When we smoke cigarettes, dozens of genes important for immune defense are altered in the epithelial cells that line the respiratory tract. Several of these changes likely increase the risk of bacterial infections, viruses, and inflammation. Now, electronic cigarettes alters those same genes and hundreds more that are important for immune defense in the upper airway.
16/06/2016hen the body is fighting an invading pathogen, white blood cells including T-cells must respond. Now, Salk Institute researchers have imaged how vital receptors on the surface of T cells bundle together when activated.
08/04/2016A diagnosis of diabetes often catches new patients off guard - for instance if they end up in the emergency room suffering from metabolic decompensation. Children are often affected by this. Their immune system destroys the insulin-producing cells in the pancreas early on in their lives, thus causing type 1 diabetes.
01/06/2015A tumor is as unique as the person who is affected by it. For a long time, it was assumed this would make treatment more difficult since cancer drugs are not able to be one hundred percent effective in targeting the affected cells. In this interview with MEDICA.de, Professor Ugur Sahin explains why it is precisely these individual mutations that make him hopeful for a new type of therapy.
22/08/2014Besides antibiotics, vaccines may be the most important development in medicine: they protect us from diseases by “introducing” our immune system to pathogens. This way, a small injection saves us from severe and potentially mortal courses of disease.
01/08/2014Bacteria lurk everywhere: on the skin, in the intestines and in every puddle. Most of them that are hanging out in the human body are good bacteria. But not all of them. Those pathogens that exhibit resistance and are thus very hard to combat are the most dangerous kind. Their spread threatens people all over the world.
22/01/2014It guards the body but can become its enemy: the immune system defends us from intruding pathogens; it is also able to cause severe diseases if it falsely recognizes the body itself as a threat. Molecular receptors in the whole body enable the immune system to “sense” what happens within.