No Data Supporting Antipsychotic Drug for Low-IQ Kids

Nevertheless the review authors say this is a common prescribing pattern. Risperidone, or Risperdal, is a second-generation antipsychotic drug. Long-term use of these drugs is associated with serious side effects, including weight gain and increased risk for type 2 diabetes.

“People who have intellectual disability are more likely to receive treatment with second- generation antipsychotics for ADHD,” said lead review author Dr. Alex Thomson. “Doctors should be aware that there is no research to demonstrate the effectiveness of risperidone for ADHD in people with intellectual disability, and should carefully monitor each case and consider alternative treatments before trying risperidone.”

Laurel Leslie, an associate professor at Tufts University School of Medicine whose research centres on paediatric mental health, concurred: “This study demonstrates that we have a gap between what we are doing clinically and what we have any research evidence for. It is an important study, as it highlights the need for careful consideration of how we treat children’s mental health issues.”

Thomson’s research group did not find one study that met their criteria for inclusion among more than 2,000 studies that they initially identified. The group analyzed 15 studies in depth, but ultimately rejected them all.

“Patients with intellectual disability and their families should be aware that without firm scientific evidence for risperidone’s effectiveness as a treatment for ADHD in this group, doctors can only prescribe on a case-by-case basis and such treatment should be regularly reviewed,” said Thomson.; Source: Health Behavior News Service