New risk factor for pregnancies

05/20/2015
Photo: Premature born baby

The researchers demonstrated that 13 percent of women born before 37 weeks of gestation gave birth prematurely at least once, compared to 9.5 percent of women born at term. Interestingly, this figure increased to 14 percent in women born before 32 weeks; © Sarah Hopkins. CC BY ND 2.0

Women who were born preterm have a higher risk of giving birth to preterm children, according to a study, published in the journal Obstetrics & Gynecology, from researchers of the CHU Sainte-Justine and the University of Montreal.

The researchers demonstrated that 13% of women born before 37 weeks of gestation gave birth prematurely at least once, compared to 9.5% of women born at term. Interestingly, this figure increased to 14% in women born before 32 weeks. "The difference is not alarming considering that according to our findings the vast majority of women born preterm gave birth at term. But it is significant enough to consider preterm birth a risk factor in monitoring pregnancies," said the senior author Dr. Anne Monique Nuyt.

Until now, it was known that low birth weight increased the risk of preterm delivery. But what about babies whose weights are low but still normal for preemies born at this age? "Our findings are unequivocal. The simple fact of being born prematurely increases the risk of premature delivery," said Ariane Boivin, lead author of the study. She explained that, to get a clear picture, the research team isolated the factor "born preterm" from the factor "birth weight for gestational age." To do this, they analyzed data from a cohort of 7,405 Quebec women who were born preterm over a period of 19 years, from 1976 to 1995, and compared it to that of women born at term.

"Knowing that being born preterm is a risk factor for expectant mothers, obstetricians could inform their patients of the warning signs of premature labour, so they can be vigilant and respond quickly if contractions occur," said Nuyt. The perspective of prematurity prevention is also among the benefits raised by the researcher. "Including preterm birth in the risk factors for pregnancy would also help to better target women most at risk when a preventive treatment becomes available," she added. Some of her colleagues at CHU Sainte-Justine are also working on developing drugs to prevent prematurity and thereby allow the fetus to continue to develop normally in the womb. "Having established with certainty a link between preterm birth and preterm delivery encourages us to continue our work to better understand the underlying biological and genetic mechanisms, in order to develop treatments that could one day prevent premature labour from occurring," she concluded.

MEDICA-tradefair.com; Source: University of Montreal

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