New Mode Found Of How Diseases Evolve

Researchers have discovered a new way that bacteria evolve into something that can make sick. The finding has implications for how scientists identify and assign risk to emerging diseases in the environment.

The researchers found that bacteria can develop into illness-causing pathogens by rewiring regulatory DNA, the genetic material that controls disease-causing genes in a body. Previously, disease evolution was thought to occur mainly through the addition or deletion of genes.

"Bacterial cells contain about 5,000 different genes, but only a fraction of them are used at any given time," Brian Coombes, lead investigator of the study, said. "The difference between being able to cause disease, or not cause disease, lies in where, when and what genes in this collection are turned on. We have discovered how bacteria evolve to turn on just the right combination of genes in order to cause disease in a host. It is similar to playing a musical instrument – you have to play the right keys in the right order to make music."

With infectious diseases on the rise, the finding has implications on how new pathogens are identified in the environment. Scientists currently monitor the risk of new diseases by assessing the gene content of bacteria found in water, food and animals.

"This opens up significant new challenges for us as we move forward with this idea of assigning risk to new pathogens," Coombes said. "Because now, we know it's not just gene content – it is gene content plus regulation of those genes."

MEDICA.de; Source: McMaster University