08/12/2005

Siemens AG Medical Solutions

New Method for Asthma Detection Using Functional MRI

One out of ten children as well as every fifth adult in Germany suffers from bronchial asthma – and this number is rising. A wide range of treatment options is available if the disease is diagnosed early and correctly. To date, lung function measurements have been used to measure airflow into and out of the lungs as well as the velocity of flow. The University Clinic in Erlangen has developed a method together with Siemens Corporate Research (SCR) in Princeton/USA that allows experts to determine which part of the lungs is involved.

The density of lung tissue plays a special role with asthmatics. During an asthma attack the muscles of the bronchial tree become tight, reducing air flow out of the lungs, that is, part of the air remains in the lungs. As specialists confirm, for asthmatics the density of the lung tissue increases only partially or not at all during exhalation. “Using functional MR of the lungs, the treating physician is able to not only detect the areals of the lungs involved but also at what points in time the damaging air remains in the lungs,“ explained Thomas Rupprecht, M.D., team manager of the clinical trial, and chief physician at the Clinic for Children and Adolescents in Bayreuth as well as visiting professor at the University of Erlangen. This has not been possible until now: conventional lung function measurements can only determine if the patient is suffering from bronchial asthma. Not one of these methods is able to determine which part of the lungs is affected.

At a young age, the performance ratio of a healthy person’s lungs is much higher than actually required - this means that a child suffering from bronchial asthma lives without side effects and performs as well as its classmates. Over time, however, the child’s performance decreases rapidly and the disease becomes evident. Conventional methods make it especially difficult to diagnose the illness at an early age. Essentially, the methods only measure the lung volume which is minimally different for sick or healthy children. Yet it is important to obtain precise information about the density of lung tissue for children and adolescents. The new method measures the actual ventilation of the lungs as well as precisely localizes pathological areals. It allows for diagnosing and treating bronchial asthma before a decrease in performance confirms the disease.
The basis for this type of measurement is the examination of the patient with magnetic resonance. In the course of several breaths, the MR system acquires images inside the lungs and loads them into the newly developed software which analyzes each cubic centimeter of the density plot. The new software is compatible with almost all MR systems from Siemens Medical Solutions. As such it is highly suitable for clinical routine as proven by the study involving over 100 patients of the University Clinic Erlangen-Nuremberg.

Bronchial asthma is a chronic inflammation and oversensitivity of the bronchial tubes which leads to periodic attacks of shortage of breath, coughing, and chest tightness. The cause is a pathological response of the lining of the air passages to different stimuli. When the pathology is already diagnosed in infancy, early therapeutic measures provide a cure or a reduction in symptoms

Siemens Medical Solutions is one of the world’s largest suppliers to the healthcare industry.The company is known for bringing together innovative medical technologies, healthcare information systems, management consulting, and support services, to help customers achieve tangible, sustainable, clinical and financial outcomes. From imaging systems for diagnosis, to therapy equipment for treatment, to patient monitors to hearing instruments and beyond, Siemens innovations contribute to the health and well-being of people across the globe, while improving operational efficiencies and optimizing workflow in hospitals, clinics, home health agencies, and doctors' offices. Employing approximately 31,000 people worldwide and operating in more than 120 countries, Siemens Medical Solutions reported sales of 7.07 billion EUR, orders of 8.12 billion EUR and group profit of 1,05 billion EUR for fiscal 2004.

Further information can be found under: www.siemens.com/medical