The study is based on the genetic analysis of more than 17,000 patients and healthy control persons. As one of the largest genetic studies on Parkinson’s disease to date, for the first time the study establishes the significance of risk genes in pathogenesis, not only for the inhabitants of the western hemisphere but also for the population in the Asia-Pacific region.
Due to the rapid technical progress in genetic analyses large patient groups can be examined for risk genes for Parkinson’s disease with relatively little time expenditure. In the process, Parkinson’s patients are typically examined from specific regions, for example Western Europe or the USA, with the result that, to date, is was unclear whether and to what extent the risk factors found can be extrapolated to other population groups worldwide.
On the basis of the study, risk genes can be named for Parkinson’s disease, which, via follow-up examinations on the affected carriers, allow predictions on the natural progression of the disease. This is a first step in the direction of future personalised risk modelling for carriers of the different gene variations.
MEDICA.de; Source: Hertie Institute for Clinical Brain Research