Medical biotechnology makes increasing efforts to analyse and characterise biological samples non-invasively. For the development of new drugs and therapies as well as for a patient-specific therapy the use of 3-D-tissue models is required. 3-D in vitro tissue models often mirror the in vivo situation better than 2-D-cell cultures. Nevertheless the existing 3-D in vitro tissue models are not suitable for large-scale application in a clinical environment or in the biotechnological research, because of their complex architecture.

At the Fraunhofer IBMT a biohybrid sensor system was developed, that allows a non-invasive characterisation of 3-D- tissue samples via impedance spectroscopy and potentiometry. The central component is a microcapillary chip that allows a hydrodynamic positioning of the biological sample.

This is the main requisition for a patient-specific therapy as well as for an advanced drug and therapy development in medical biotechnology. The qualification of this newly developed system for the evaluation of new drugs and therapies is already shown on genetically modified 3-D-tumor models and 3-D-heart muscle spheroids.

MEDICA.de; Source: Fraunhofer-Institut für Biomedizinische Technik (IBMT)