Mechanisms of Memory Identified

This demonstrates they have identified cellular and molecular mechanisms in the brain that may provide a key to understanding processes of recognition memory. Zafar Bashir, Professor of Cellular Neuroscience, who led the team at Bristol University said: “This is a major step forward in our understanding of recognition memory. We have been able to show that key processes controlling synaptic communication are also vital in learning and memory.”

The ability to recognise elements in the surrounding environment such as faces or places, as well as the ability to learn about that environment, is crucial to our normal functioning in the world. But the actual mechanisms and changes that occur in the brain and allow learning to happen are still not very well understood. Dr Sarah Griffiths, lead author on the paper, explained: “Nerve cells in the perirhinal cortex of the brain are known to be vital for visual recognition memory.

Using a combination of biological techniques and behavioural testing, we examined whether the mechanisms involved in synaptic plasticity are also vital for visual recognition memory.” In their experiments, the researchers were able to identify a key molecular mechanism that controls synaptic plasticity in the perirhinal cortex.

They then demonstrated that blocking the same molecular mechanism that controls synaptic plasticity also prevented visual recognition memory in rats. This shows that such memory relies on specific molecular processes in the brain. Bashir added: “The next step is to try to understand the processes that enable visual memories to be held in our brains for such long periods of time, and why these mechanisms begin to break down in old age.”

MEDICA.de; Source: University of Bristol