“Our findings suggest that miRNAs might help detect the disease earlier and differentiate it from noncancerous conditions,” says first author Mark Bloomston, assistant professor of surgery at Ohio State’s James Cancer Hospital and Solove Research Institute. “We also found that we could predict which patients would do better or worse based on a just a few miRNAs. Such correlations with survival have previously been lacking in pancreatic cancer,” Bloomston says.
For this study, Bloomston and his colleagues examined tumour samples from 65 patients with adenocarcinoma of the pancreas, the most common form of the disease. They extracted miRNA from isolated tumour cells and from adjacent noncancerous pancreatic tissue. In addition, they isolated miRNA from the pancreatic cells of people who had undergone surgery for chronic pancreatitis, an inflammation of the pancreas often associated with pancreatic cancer. Perhaps surprisingly, the miRNAs that could discriminate between long- and short-term survivors were not among those that were specific to pancreatic cancer.
MicroRNAs, first discovered less than 15 years ago, help control the type and quantity of proteins that cells naturally make by modifying other genes. Research over the past few years has shown that they also play an important role in cancer. More than 300 different human miRNAs have been identified so far.
Pancreatic cancer is expected to strike 37,170 Americans and to kill 33,370 others this year, making it the fourth-leading cause of cancer death in both men and women. The number of new cases nearly equals the number of deaths because the disease is difficult to diagnosis early and because there have been few treatment advances.
MEDICA.de; Source: Ohio State University