Making Headway on Beta-blockers and Sleep

Photo: Drugs

Beta-blockers - a medication
commonly prescribed for cardio-
vascular issues, anxiety or hyper-
Wavebreakmedia Ltd

"Beta-blockers have long been associated with sleep disturbances, yet until now, there have been no clinical studies that tested whether melatonin supplementation can improve sleep in these patients," explained Doctor Frank Scheer, investigator on this study. "We found that melatonin supplements significantly improved sleep."

The research team analyzed 16 hypertensive patients who regularly took beta-blockers as treatment for their hypertension. The study participants were given either a melatonin supplement or placebo to take each night before bed. To avoid bias, neither the participants nor the researchers knew which pill they were taking. During the three week study, the participants spent two separate four-day visits in lab. While in the lab, the researchers assessed the participants' sleep patterns and found a 37-minute increase in the amount of sleep in the participants who received the melatonin supplement compared to those who received placebo. They also found an eight percent improvement of sleep efficiency and a 41 minute increase in the time spent in Stage 2 sleep, without a decrease in slow wave sleep or REM sleep.

"Over the course of three weeks, none of the study participants taking the melatonin showed any of the adverse effects that are often observed with other, classic sleep aids. There were also no signs of 'rebound insomnia' after the participants stopped taking the drug," explained Scheer. "In fact, melatonin had a positive carry-over effect on sleep even after the participants had stopped taking the drug."

The researchers caution that while this data is promising for hypertensive patients taking beta-blockers, more research is needed to determine whether patients taking beta-blockers for causes other than hypertension could also benefit from melatonin supplementation.; Source: Brigham and Women's Hospital