Low Dose of Caffeine May Damage Heart

Photo: Pull-over does not fit over pregnant belly

In mice, caffeine during pregnancy
shows negative effects on the
offspring for their life-time;
© Hemera

A new study shows that the equivalent of one dose of caffeine (just two cups of coffee) ingested during pregnancy may be enough to affect foetal heart development and then reduce heart function over the entire lifespan of the child. In addition, the researchers also found that this relatively minimal amount of exposure may lead to higher body fat among males, when compared to those who were not exposed to caffeine. Although the study was in mice, the biological cause and effect described in the research paper is plausible in humans, the researchers say.

According to Scott Rivkees, a senior researcher on the study, "Our studies raise potential concerns about caffeine exposure during very early pregnancy, but further studies are necessary to evaluate caffeine's safety during pregnancy."

To reach their conclusion researchers studied four groups of pregnant mice under two sets of conditions for 48 hours. The first two groups were studied in "room air," with one group having been injected with caffeine and another injected with saline solution. The second two groups were studied under conditions where ambient oxygen levels were halved, with one group receiving caffeine and the other receiving saline solution. They found that under both circumstances, mice given caffeine produced embryos with a thinner layer of tissue separating some of the heart's chambers than the group that was not given caffeine.

The researchers then examined the mice born from these groups to determine what long-term effects, if any, caffeine had on the offspring. They found that all of the adult males exposed to caffeine as foetuses had an increase in body fat of about 20 percent, and decreased cardiac function of 35 percent when compared to mice not exposed to caffeine.

MEDICA.de; Source: Federation of American Societies for Experimental Biology