Level of Mesothelin Plays Important Role

The protein called mesothelin appears to play an important role in promoting pancreatic cancer growth, said the senior author Dr. Qizhi Yao, professor of surgery – vascular surgery at BCM. She and colleagues carried out the studies of the protein that is found on the tumor cells’ surface. “Mesothelin is found in other cancers for several years,” said Yao. “However, we didn’t know the role it played in pancreatic cancer.” In fact, the researchers found very high levels of mesothelin in 18 of 21 samples of patient’s pancreatic tissues compared to amounts found in nearby normal tissues. In studies of this protein in the lab, pancreatic cancer cell lines that produced high levels of mesothelin grew faster and spread more than those in which mesothelin levels were lower.

Pancreatic cancer cells grew and spread faster in mice whose tumors expressed high levels of mesothelin than in those whose cancer did not, said the researchers, who conducted the studies in an immune deficient mouse. Making a treatment vaccine of virus-like particles that contained mesothelin, researchers injected mice having pancreatic cancer with this vaccine three times. Virus-like particles have the unique property of inducing protective immune responses but they lack the infectious capacities of the original virus. Tumor growth in the immunized mice slowed and in some cases the tumor disappeared. The average life span for the mice not treated was four weeks. The immunized mice survived five weeks longer than those not treated.

Researchers found that the immunization works by suppressing production of key immune system cells that suppress the body’s ability to fight the tumor. The researchers said pancreatic cancers produce these cells, called T regulatory cells, as a protective measure. “If we are able to see the same results in humans, this would allow us to incorporate a combination therapy to treat the tumor,” Yao said. “Treatment with a single drug is not effective.”

MEDICA.de; Source: Baylor College of Medicine