However, this direct interaction may respond to therapeutic intervention. The study by Doctor Volker Siffrin and Professor Frauke Zipp ( now University Medical Center Johannes Gutenberg University) has now been published.
Multiple sclerosis is an autoimmune disease in which a person’s own immune system attacks the central nervous system. Research has shown that MS is caused by damage to the protective myelin sheath, an insulating substance that surrounds nerve processes and is critical for transmission of nerve impulses.
Research has also indicated that direct damage to neurons is prominent in early disease stages. “The contribution of direct neuronal damage to MS pathology has been debated since the first description of the disease,” explained Zipp. “Although many different theories about possible underlying mechanisms have been proposed – such as neuron damage being a secondary effect of the disrupted myelin sheath – actual events leading to neural damage are not well understood.”
To investigate processes in the living organisms, Zipp and her colleagues used two-photon laser scanning microscopy (TPLSM), with which they studied the role immune cells play in neuronal damage in mice with experimental autoimmune encephalomyelitis (EAE), an animal model of MS. They observed direct synapse-like interactions between immune cells and neurons.
Immune cells called Th17 cells, which have been linked to autoimmune inflammation, induced elevated calcium levels in the neurons, which in the long run are toxic to the cells. Normally, calcium within the neuron plays a crucial role in exciting nerve cells as well as muscle cells.
This is significant because fluctuations in neuronal intracellular calcium levels that are linked to cell injury are partially reversible when the researchers expose the lesions of the animals to compounds used to treat excitotoxicity.
These results highlight a specific interaction between the immune system and the nervous system, implicating direct neuronal damage in autoimmune-mediated inflammation.
MEDICA.de; Source: Max-Delbrück-Centrum für Molekulare Medizin (MDC) Berlin-Buch