Nutrition: High-protein Diets Increase Risk of Kidney Disease

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A high-protein diet increases the chance of developing kidney stones and other renal diseases in rats;
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An experiment by scientists at the University of Granada, Spain, shows a high-protein diet increases the chance of developing kidney stones and other renal diseases in rats.

High-protein diets, increase the long-term risk of developing kidney disease and have a negative effect on renal urinary and morphological markers. What is more, they may promote serious pathologies like nephrolithiasis (calcium kidney stones) because they drastically reduce urinary citrate (an inhibitor of calcium salt crystallization) and urinary pH, and increase urinary calcium (to compensate for the metabolic acidity caused by excess protein). University of Granada scientists have proven this in an experiment in rats that examined the effects of a high-protein diet on renal urinary, plasma and morphological parameters.

The researchers studied 20 Wistar rats, divided into two groups of 10. The first group was fed a high-protein diet of commercial hydrolyzed protein supplements with a 45% protein level. The control group was fed a normal protein diet. The experiment lasted 12 weeks, which is the equivalent of 9 years in human terms.

The results showed that the rats on a high-protein diet lost up to 10% of their body weight over the 12 weeks with no improvement in their plasma lipid profile. Moreover, urinary citrate in these rats was 88% lower and urinary pH was 15% more acidic. In the animals fed a high-protein diet, kidney weight increased by 22%, glomerular area—the network of capillaries that filter blood in the kidneys—by 13%, and the mesangium—a collagen structure surrounded by these capillaries—by 32%.

The results of this study lead the principle author, Dr Virginia A. Aparicio of the University of Granada Department of Physiology, to stress the need to closely monitor anyone on a high-protein diet. They can have serious long-term adverse effects on their health.

She warns that the negative effects of high-protein diets on the kidney also depend on the presence of other nutrients in the diet. “Eating large amounts of fruit and vegetables reduces the risk of kidney stones forming—probably due to their high potassium and magnesium content, which compensates for the acidity of the high-protein diet", Aparicio concludes.; Source: University of Granada