Russian researchers of the Moscow Regional Scientific-Research Clinical Institute "MONIKI” hope that the fluorescence intensity allows to foresee how successful the treatment would be and how to select the most optimal irradiation conditions.

Multiple diseases are accompanied by increase of porphyrins in the cells. Being extremely sensitive to the red component of spectrum, the tissues with high content of porphyrins become targets to laser irradiation, which activates defense functions and the cell division process.

The tissues containing porphyrins glow upon irradiation, and fluorescence intensity depends on the quantity of porphyrins. The Moscow specialists compared the data on porphyrin content in the area of ulcer with the laser therapy efficiency.

All experiments were carried out with a helium-neon laser. The group under observation included 192 patients with protractedly nonhealing ulcers. Each of the patients was provided with seven to ten laser therapy sequences, in the course of them the researchers checked porphyrins' efficiency and spectrum of fluorescence on the surface of affected and healthy tissues adjacent to them.

To this end, during the scheduled endoscopic examination the spectrum analyser optical fiber was passed through the biopsy canal and brought to the examined section. It showed that depending on the content of porphyrins in the wound material, laser irradiation causes either medicinal effect or overdosage effect.

Probably, laser therapy could help such patients but commonly accepted radiation doses do not suit them. The optimal dose should be selected individually, and this can be done, according to researchers' opinion, based on spectra of porphyrins' fluorescence.; Source: Informnauka Agency