Experts call for standard list of essential diagnostic tests


Similar to long-established list of essential medicines, a standard list of essential diagnostic test could help improve capacity and quality of testing in developing nations.

Photo: Diagnostic test in a laboratory

A standard list of diagnostic test is necessary for increasing the global health. ©

In a western doctor's office or hospital, patients don't think twice about giving a blood or urine sample that can tell if they have a disease or infection, or show if their medicines are working. The samples get rushed to a testing lab with modern equipment that's held to high quality standards.

But in developing nations, many of those tests aren't available. Or if they are, doctors may not put much faith in them because of the state of their country's testing labs.

And some of those tests - which can detect emerging viruses like Zika or Ebola - could make the difference in outbreaks that can quickly affect the rest of the world.

Now, a team of experts has put together a list of the key tests that every country should have available, with high quality standards, in hopes of changing this situation.

Writing in the New England Journal of Medicine, they put forth a list of tests that syncs with another, much more established list: the Model List of Essential Medicines (EML) published by the World Health Organization.

For the last 40 years, the EML has guided billions of dollars in spending on more than 300 vital pharmaceuticals by government agencies, healthcare organizations, and charity groups worldwide. When a medicine makes it onto the list, it jumpstarts a global health funding mechanism to make sure the medicines flow to developing countries.

A parallel Model List of Essential Diagnostics, which the new paper proposes, could make the most of that spending. When performed correctly, these tests can help health teams figure out which of the EML medications a patient needs and at what dose, track their response to treatment, and monitor for medication toxicity.

"Efficient delivery of healthcare requires diagnostic testing," says Lee F. Schroeder, M.D., Ph.D., lead author of the new paper and an assistant professor of pathology at the University of Michigan Medical School. "You can't treat what you can't test. This list includes the most critical tests for diagnosing conditions, monitoring drug effects and toxicity, reducing over-prescription of antibiotics, and enabling surveillance of infectious threats."

Compiling the list

Schroeder and his colleagues, including Timothy Amukele, M.D., Ph.D. of Johns Hopkins University, scoured expert databases on diagnostic testing to determine which tests are needed to support the use of each medicine on the EML.

The resulting list includes 147 essential laboratory tests in 57 categories. A single diagnostic test can guide the use of many different EML drugs.

The paper includes a table of 19 test categories that can guide the use of 10 or more EML medicines including:

  • Accurate counts of different types of blood cells in a sample, which can directly affect the use of 136 different items on the EML list.
  • Accurate blood tests assessing liver toxicity, which can support the use of 104 EML drugs.
  • Accurate blood tests for kidney function, which should be used in conjunction with more than 80 items on the EML
  • Standardized use of microscope-based diagnostic tests, which can guide the best use of 85 essential medicines, most of them aimed at treating and preventing infectious disease.
  • Urinalysis, when performed well, can monitor the use of 64 EML drugs.
  • Tests that look for DNA signatures from an infectious microbe, or isolate and grow that microbe from a sample taken from a patient. These tests can make a difference in outbreaks and the use of 62 EMLs.

"Many developing countries have high quality central public health labs in large cities; the missing piece in global health is a network of smaller, but still high quality, labs throughout the country," says Schroeder. Poor test quality, or inappropriate storage of testing materials, can erode doctors' trust in test results.; University of Michigan Health System

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