Researchers studied clots removed from the brain blood vessels of 25 stroke victims. The clots were retrieved during treatment using a novel mechanical clot-retrieval device called the MERCI (Mechanical Embolus Removal in Cerebral Ischemia) Retriever. The removed clots were analyzed under the microscope to compare their component structures.

"Unexpectedly, no two retrieved clots looked the same, even though all were constructed from the same basic components of fibrin, white cells and red blood cells," said Dr. Victor Marder, professor of haematology and oncology at the David Geffen School of Medicine at UCLA and a UCLA Stroke Center member. "The same components were involved in both the newly formed and mature, enlarging clots. Red blood-cell accumulations had previously been considered to dominate the structure of clots that formed within a heart chamber, but our results suggest that red cells often accumulated on clots after impaction in the brain artery."

The findings could lead to better therapies to prevent clots, clear blockages and reverse strokes in the crucial first hours after they occur. "This could potentially change the way we treat clots," said Dr. Jeffrey Saver, professor of neurology at the David Geffen School of Medicine at UCLA and co-director of the UCLA Stroke Center. "Now that we can retrieve clots, we can analyze their molecular composition and determine the combination of mechanical therapies and clot-dissolving agents most likely to allow us to open up arteries."

This study marks the first time that so many blockages, almost all of which were clots, have been analyzed in such detail.; Source: University of California - Los Angeles