Best Detection with Ultrasound plus Mammography

Photo: Mammography

Mammography should be used
in combination to ultrasound;
© NCI Visuals Online

Wendie A. Berg, M.D., Ph.D., of the American Radiology Services Inc., Johns Hopkins Green Spring, Lutherville, Md., and colleagues conducted a study to compare the diagnostic effectiveness of screening breast mammography plus ultrasound versus mammography alone in women at increased risk of breast cancer. The study included 2,809 women with dense breast tissue who were randomized to undergo mammographic and ultrasonographic examinations.

Forty participants (41 breast lesions) were diagnosed with cancer: 8 suspicious on both ultrasound and mammography; 12 on ultrasound alone; 12 on mammography alone; and 8 participants (involving 9 breast lesions) on neither. The diagnostic yield for mammography was 7.6 cancers per 1,000 women screened (20/2,637); 31 cancers were diagnosed in 2,637 participants by the combination of mammography plus ultrasound, producing a yield of 11.8 per 1,000 women, and an increased yield due to ultrasound of 4.2 per 1,000 over mammography alone (or an additional 1.1 to 7.2 cancers per 1,000 high-risk women).

The diagnostic accuracy of mammography was 0.78; for ultrasound, 0.80; and for combined mammography plus ultrasound, 0.91. The positive predictive value of biopsy recommendation after full diagnostic workup was 19 of 84 for mammography (22.6 percent), 21 of 235 for ultrasound (8.9 percent), and 31 of 276 for combined mammography plus ultrasound (11.2 percent).

The false-positive rate for mammography was 4.4 percent; for ultrasound, 8.1 percent; and for combined mammography plus ultrasound, 10.4 percent. “Our results should be interpreted in the context of recent guidelines recommending annual MRI in women at very high risk of breast cancer,” the authors conclude.

MEDICA.de; Source: University of California, San Diego