Researchers led of Professor Jennifer G. Levitt found aberrant growth rates in areas of the brain implicated in the social impairment, communication deficits and repetitive behaviours that characterise autism.
Autism is thought to affect one in 110 children in the United States, and many experts believe the numbers are growing. Despite its prevalence, little is known about the disorder, and no cure has been discovered. Normally, as children grow into teenagers, the brain undergoes major changes. This highly dynamic process depends on the creation of new connections, called white matter, and the elimination, or "pruning," of unused brain cells, called gray matter. As a result, our brains work out the ideal and most efficient ways to understand and respond to the world around us.
Although most children with autism are diagnosed before they are 3 years old, this new study suggests that delays in brain development continue into adolescence. "Because the brain of a child with autism develops more slowly during this critical period of life, these children may have an especially difficult time struggling to establish personal identity, develop social interactions and refine emotional skills," said Xue Hua, co-author of the study. "This new knowledge may help to explain some of the symptoms of autism and could improve future treatment options."
The researchers used a type of brain-imaging scan called a T1-weighted MRI, which can map structural changes during brain development. To study how the brains of boys with autism changed over time, they scanned 13 boys diagnosed with autism and a control group of seven non-autistic boys on two separate occasions. The boys ranged in age from 6 to 14 at the time of the first scan; on average, they were scanned again approximately three years later.
By scanning the boys twice, the scientists were able to create a detailed picture of how the brain changes during this critical period of development. Besides seeing that the white-matter connections between those brain regions that are important for language and social skills were growing much slower in the boys with autism, they found a second anomaly: In two areas of the brain — the put amen, which is involved in learning, and the anterior cingulate, which helps regulate both cognitive and emotional processing — unused cells were not properly pruned away.
"Together, this creates unusual brain circuits, with cells that are overly connected to their close neighbours and under-connected to important cells further away, making it difficult for the brain to process information in a normal way," Hua said. "The brain regions where growth rates were found to be the most altered were associated with the problems autistic children most often struggle with — social impairment, communication deficits and repetitive behaviour," she added.
MEDICA.de; Source: University of California, Los Angeles